The Grand Ducal Family of Luxembourg consists of the extended family of the sovereign Grand Duke. The medieval duchy of Luxembourg was elevated to a grand duchy in 1815 when William V, Prince of Orange ascended the grand ducal throne as its first holder.

The male-line descendants of Grand Duchess Charlotte hold the titles Prince(ss) of Luxembourg and Prince(ss) of Nassau with the style of His/Her Royal Highness (coming from their status as male-line descendants of Duke Robert of Parma). The title Prince of Bourbon-Parma was relinquished by Grand Duke Jean in 1986, but he and his relatives have kept the style of His/Her Royal Highness.